From the party to the therapy – MDMA as an alternative for the existing methods of Post-traumatic Stress Disorder treatment

Introduction: Post-traumatic Stress Disorder (PTSD) is a mental illness caused by exposure to traumatic event. The current treatment includes trauma-focused psychotherapy along with selective serotonin reuptake inhibitors (SSRI). It estimated that for about 40-60% of patients it does not bring the desired improvement, which prompted scientists look new methods pharmacotherapy. most promising compound MDMA. Material and methods: purpose this paper review publications from years 2020-2022 available on PubMed platform using MDMA in PTSD treatment, words: MDMA, PTSD, PTSD. Discussion: (3,4-methylenedioxymethamphetamine) psychoactive substance increases brain levels serotonin, dopamine norepinephrine. Studies show reduces symptoms severe comparing placebo treatment. Patients reported improvement terms well-being, number nightmares, sleep disorders, self-perception or interpersonal relationships. positive effects therapy were long-lasting. They persisted 12 months after end According research, concomitant e.g. eating disorders reducing alcohol consumption, without increasing risk abuse other substances itself. In addition, believed improve allowing revisit event negative symptoms. Side are less serious occur often than case previously used SSRIs. Conclusions: Abovementioned observations MDMA-assisted alternative existing brings hope treatment-resistant course. Keywords: N-Methyl-3,4-methylenedioxyamphetamine, psychotherapy,